Dietary supplements That Can Be Lethal When Mixed With Prescription Medication

Delly Bezoss

On a regular basis dietary supplements, reminiscent of calcium, vitamin Okay, and potassium, can flip lethal when mixed with prescription drugs.

Vitamin D supplements

In the event you do not suppose you are getting sufficient vitamin D, you could need to strive dietary supplements.

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Nutritional vitamins are important for sustaining optimum physique features, from regulating heartbeats to therapeutic wounds.

On the whole, individuals can get a lot of the nutritional vitamins they want from consuming a well-balanced weight loss plan, however docs may counsel or prescribe dietary supplements in severely poor sufferers. The Centers for Disease Control and Prevention has discovered that People are notably poor in vitamin B6, iron,

vitamin D

, and vitamin C.

Although gross sales for dietary supplements, together with nutritional vitamins, have skyrocketed throughout the pandemic, taking these dietary supplements together with some prescription drugs can result in harmful well being outcomes.

Robert Alesiani, the chief pharmacotherapy officer at Tabula Rasa Healthcare, spoke with Insider concerning the on a regular basis nutritional vitamins that would flip deadly when mixed with sure prescription drugs.

“It is all the time good to have your physician or a pharmacist know the dietary supplements you are taking together with your prescription drugs,” Alesiani stated.

Combining St. John’s wort with HIV or posttransplant drugs might be deadly.

St. John's Wort supplement bottle sitting on pharmacy shelf

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St. John’s Wort is an natural treatment routinely prescribed for


in Europe. Some managed research have discovered that St. John’s wort improves signs of melancholy in sufferers with delicate to average types of the sickness.

Alesiani stated the herb can set off the manufacturing of enzymes and proteins — discovered within the intestine, liver, and intestines — that expedite the velocity wherein medicine are absorbed by the physique. The speedy absorption can scale back the efficacy of medicines, for the reason that physique excretes the medicine too rapidly earlier than they can be utilized. 

Alesiani added that St. John’s wort may trigger hurt by decreasing the efficacy of antiviral medicine referred to as protease inhibitors, which block the replication of HIV cells within the physique.

Moreover, combining some antidepressants with St. John’s wort may additionally improve the danger of serotonin toxicity, which may result in diarrhea, fever, seizures, and typically dying, Mayo Clinic stated.

Calcium, aluminum, and iron dietary supplements carry a optimistic cost that blocks the absorption of antibiotics.

A staged photo showing pills spilling out of an orange bottle.

A staged picture exhibiting capsules spilling out of an orange bottle.

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Calcium, aluminum, and iron dietary supplements all carry a optimistic cost (referred to as a “cation”) that bind to and will block some absorption of various


used to deal with quite a lot of ailments, together with


, bladder infections, and the plague. 

“If a affected person’s taking antibiotics for an an infection, however they’re taking it together with calcium dietary supplements, it could block the absorption of these antibiotics, and so they could not get the ample ranges that they should handle that an infection,” Alesiani stated.

Antibiotics that turn out to be much less efficient when mixed with these dietary supplements embody:

  • Ciprofloxacin, a drugs that belongs to the fluoroquinolones class of antibiotics. It’s used to deal with bacterial infections in many alternative components of the physique.
  • Ofloxacin, a drugs that belongs to the fluoroquinolones class of antibiotics. Ofloxacin can deal with pneumonia, bladder infections, and prostate infections.
  • Demeclocycline, a drugs that belongs to the tetracyclines class of antibiotics. Demeclocycline can deal with respiratory tract infections, pores and skin and eye infections, and infections unfold by ticks, lice, and mites.
  • Omadacycline, a drugs that belongs to the tetracyclines class of antibiotics. Omadacycline can be utilized to deal with bacterial pneumonia and acute bacterial pores and skin and pores and skin construction infections.

Potassium dietary supplements mixed with coronary heart medicine can result in a harmful improve in blood strain.


Bananas comprise a lot of potassium, which features as an electrolyte and nutrient.

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Potassium helps the physique regulate heartbeat, decrease blood strain, and aids in muscle and nerve functioning. An excessive amount of potassium can result in dangerous modifications in coronary heart rhythm and compromise kidney operate, Insider beforehand reported.

Alesiani stated potassium dietary supplements used together with drugs to deal with coronary heart issues or


may trigger blood ranges to extend to harmful ranges. These drugs embody ACE inhibitors and angiotensin receptor blockers — which loosen up the veins and arteries to decrease blood strain — aldosterone antagonists, and different potassium-sparing diuretics, which deal with hypertension by making you pee out extra salt to make it simpler to your coronary heart to pump blood. 

Vitamin Okay can scale back or improve the efficacy of lifesaving medicine that decreases blood clots.

vitamin k supplement pills and bottle

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Vitamin Okay is used for quite a lot of features, reminiscent of sustaining bone power and defending in opposition to

coronary heart illness

, and it is particularly essential in wound-healing. The vitamin turns blood from a liquid to a gel-like consistency that then types a scab, stopping the physique from bleeding to dying. 

Individuals who have had a coronary heart assault or shaped a harmful blood clot within the lungs or veins are prescribed warfarin, a blood-thinning medicine that hinders clotting. Taking

vitamin Okay

dietary supplements with warfarin would both scale back or improve the efficacy of this drug, Alesiani stated, rising the danger of harmful clotting or bleeding.

“As a result of nutritional vitamins and different drugs can be found over-the-counter does not essentially imply that they are thought-about protected in all circumstances,” Alesiani stated.

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