Examine Confirms Good thing about Dietary supplements for Slowing Age-Associated Macular Degeneration

Delly Bezoss

Abstract: The AREDS2 dietary complement that substitutes antioxidants lutein and zeaxanthin for beta-carotene reduces the chance of age-related macular degeneration development, a brand new research reveals.

Supply: NIH

The Age-Associated Eye Illness Research (AREDS and AREDS2) established that dietary dietary supplements can sluggish development of age-related macular degeneration (AMD), the commonest explanation for blindness in older People. In a brand new report, scientists analyzed 10 years of AREDS2 information.

They present that the AREDS2 formulation, which substituted antioxidants lutein and zeaxanthin for beta-carotene, not solely reduces threat of lung most cancers because of beta-carotene, however can be more practical at decreasing threat of AMD development, in comparison with the unique formulation.

A report on the research, funded by the Nationwide Institutes of Well being, printed in JAMA Ophthalmology.

“As a result of beta-carotene elevated the chance of lung most cancers for present people who smoke in two NIH-supported research, our purpose with AREDS2 was to create an equally efficient complement formulation that may very well be utilized by anybody, whether or not or not they smoke,” mentioned Emily Chew, M.D., director of the Division of Epidemiology and Medical Software on the Nationwide Eye Institute (NEI), and lead writer of the research report.

“This 10-year information confirms that not solely is the brand new formulation safer, it’s really higher at slowing AMD development.”

AMD is a degenerative illness of the retina, the light-sensitive tissue in the back of the attention. Progressive dying of retinal cells within the macula, the a part of the retina that gives clear central imaginative and prescient, finally results in blindness. Therapy can sluggish or reverse imaginative and prescient loss; nonetheless, no remedy for AMD exists.

The unique AREDS research, launched in 1996, confirmed {that a} dietary complement formulation (500 mg vitamin C, 400 worldwide items vitamin E, 2 mg copper, 80 mg zinc, and 15 mg beta-carotene) may considerably sluggish the development of AMD from average to late illness.

Nonetheless, two concurrent research additionally revealed that individuals who smoked and took beta-carotene had a considerably larger threat of lung most cancers than anticipated.

In AREDS2, begun in 2006, Chew and colleagues in contrast the beta-carotene formulation to at least one with 10 mg lutein and a pair of mg zeaxanthin as an alternative. Like beta-carotene, lutein and zeaxanthin are antioxidants with exercise within the retina. The beta-carotene-containing formation was solely given to individuals who had by no means smoked or who had give up smoking. 

On the finish of the five-year AREDS2 research interval, the researchers concluded that lutein and zeaxanthin didn’t enhance threat for lung most cancers, and that the brand new formation may scale back the chance of AMD development by about 26%.

After the completion of the five-year research interval, the research individuals have been all provided the ultimate AREDS2 formation that included lutein and zeaxanthin as an alternative of beta-carotene.

On this new report, the researchers adopted up with 3,883 of the unique 4,203 AREDS2 individuals a further 5 years from the tip of the AREDS2 research in 2011, accumulating info on whether or not their AMD had progressed to late illness, and whether or not they had been recognized with lung most cancers.

AMD is a degenerative illness of the retina, the light-sensitive tissue in the back of the attention. Picture is within the public area

Although all of the individuals had switched to the formulation containing lutein and zeaxanthin after the tip of the research interval, the comply with up research continued to point out that beta-carotene elevated threat of lung most cancers for individuals who had ever smoked by practically double.

There was no elevated threat for lung most cancers in these receiving lutein/zeaxanthin.

As well as, after 10 years, the group initially assigned to obtain lutein/zeaxanthin had a further 20% diminished threat of development to late AMD in comparison with these initially assigned to obtain beta-carotene.

“These outcomes confirmed that switching our formulation from beta-carotene to lutein and zeaxanthin was the correct selection,” mentioned Chew.

Funding: The research was funded by the NEI Intramural program (EY000546) and thru contracts (AREDS2 contract HHS-N-260-2005-00007-C; ADB contract NO1-EY-5-0007; AREDS Contract NOI-EY-0-2127, and contract HHS-N-263-2013-00005-C).

The AREDS2 contracts have been supported by the NIH Workplace of Dietary Workplace of Dietary Dietary supplements, the Nationwide Middle for Complementary and Integrative Well being, the Nationwide Institute on Getting older, the Nationwide Coronary heart, Lung, and Blood Institute, and the Nationwide Institute of Neurological Issues and Stroke.

The research happened on the NIH Medical Middle.

About this age-related macular degeneration analysis information

Creator: Lesley Earl
Supply: NIH
Contact: Lesley Earl – NIH
Picture: The picture is within the public area

Unique Analysis: Closed entry.
Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression” by Chew EY, et al. JAMA Opthalmology


Lengthy-term Outcomes of Including Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Dietary supplements on Age-Associated Macular Degeneration Development


After the Age-Associated Eye Illness Examine 2 (AREDS2) research, the beta carotene part was changed by lutein/zeaxanthin for the event of the revised AREDS complement. Nonetheless, it’s unknown if the elevated threat of lung most cancers noticed in these assigned beta carotene persists past the conclusion of the AREDS2 trial and if there’s a good thing about including lutein/zeaxanthin to the unique AREDS complement that may be noticed with long-term follow-up.


See additionally

This shows an older lady

To evaluate 10-year threat of creating lung most cancers and late age-related macular degeneration (AMD).

Design, Setting, and Members  

This was a multicenter epidemiologic follow-up research of the AREDS2 scientific trial, performed from December 1, 2012, to December 31, 2018. Included within the evaluation have been individuals with bilateral or unilateral intermediate AMD for a further 5 years after scientific trial. Eyes/individuals have been censored on the time of late AMD growth, dying, or loss to follow-up. Information have been analyzed from November 2019 to March 2022.


In the course of the scientific trial, individuals have been randomly assigned primarily to lutein/zeaxanthin and/or ω-3 fatty acids or placebo and secondarily to no beta carotene vs beta carotene and low vs excessive doses of zinc. Within the epidemiologic follow-up research, all individuals acquired AREDS2 dietary supplements with lutein/zeaxanthin, nutritional vitamins C and E, and zinc plus copper. Outcomes have been assessed at 6-month phone calls. Analyses of AMD development and lung most cancers growth have been performed utilizing proportional hazards regression and logistic regression, respectively.

Essential Outcomes and Measures  

Self-reported lung most cancers and late AMD validated with medical information.


This research included 3882 individuals (imply [SD] baseline age, 72.0 [7.7] years; 2240 ladies [57.7%]) and 6351 eyes. At 10 years, the chances ratio (OR) of getting lung most cancers was 1.82 (95% CI, 1.06-3.12; P = .02) for these randomly assigned to beta carotene and 1.15 (95% CI, 0.79-1.66; P = .46) for lutein/zeaxanthin.

The hazard ratio (HR) for development to late AMD evaluating lutein/zeaxanthin with no lutein/zeaxanthin was 0.91 (95% CI, 0.84-0.99; P = .02) and evaluating ω-3 fatty acids with no ω-3 fatty acids was 1.01 (95% CI, 0.93-1.09; P = .91).

When the lutein/zeaxanthin fundamental results evaluation was restricted to these randomly assigned to beta carotene, the HR was 0.80 (95% CI, 0.68-0.92; P = .002).

A direct evaluation of lutein/zeaxanthin vs beta carotene confirmed the HR for late AMD was 0.85 (95% CI, 0.73-0.98; P = .02). The HR for low vs excessive zinc was 1.04 (95% CI, 0.94-1.14; P = .49), and the HR for no beta carotene vs beta carotene was 1.04 (95% CI, 0.94-1.15; P = .48).

Conclusions and Relevance  

Outcomes of this long-term epidemiologic follow-up research of the AREDS2 cohort counsel that lutein/zeaxanthin was an acceptable substitute for beta carotene in AREDS2 dietary supplements. Beta carotene utilization practically doubled the chance of lung most cancers, whereas there was no statistically vital elevated threat with lutein/zeaxanthin. In comparison with beta carotene, lutein/zeaxanthin had a possible helpful affiliation with late AMD development.

Study Confirms Benefit of Supplements for Slowing Age-Related Macular Degeneration

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